subacute sclerosing panencephalitis (Dawson disease, SSPE)

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Etiology

Epidemiology

  • 85% < 15 years old
  • 3-10 times more likely in males
  • occurs years after clinical measles

Pathology

  • dementia in children & occasionally in adolescents due to persistent replication of the measles virus in the brain many years after initial infection

Clinical manifestations

Laboratory

Diagnostic procedures

  • characteristic periodic EEG

Radiology

Management

  • no treatment uniformly effective
  • isoprinosine controversial

More general terms

References

  1. Harrison's Principles of Internal Medicine, 13th ed. Isselbacher et al (eds), McGraw-Hill Inc. NY, 1994, pg 144
  2. 2.0 2.1 NORD: National Organization for Rare Disorders Subacute Sclerosing Panencephalitis https://rarediseases.org/rare-diseases/subacute-sclerosing-panencephalitis/
  3. National Institute of Neurological Disorders and Stroke (NINDS) Subacute Sclerosing Panencephalitis Information Page https://www.ninds.nih.gov/Disorders/All-Disorders/Subacute-Sclerosing-Panencephalitis-Information-Page

Patient information

subacute sclerosing panencephalitis patient information

Database