ganglioglioma; dysembryonic neuroepithelial neoplasm
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Introduction
Lumped with dysembryonic neuroepithelial neoplasm
- prognosis & treatment the same[2]
Epidemiology
- < 30 years of age[2]
Pathology
- mixed tumor of neuronal & glial derived cells
- may occur anywhere CNS (brain or spinal cord)
- majority occur in temporal lobe
Genetics
- rare TSC2 gene polymorphism at 3' splice site of intron 4 appears with higher frequency in sporadic gangliogliomas
Clinical manifestations
- medication-resistant tumors (90%)
Radiology
Complications
- anticonvulsant-resistant seizures (90%)
Management
- neurosurgery: surgical resection
- prognosis:
- rarely limits life expectancy if completely resected[2]
More general terms
References
- ↑ Platten et al. J Neuropathol Exp Neurol 56:806-10, 1997
- ↑ Jump up to: 2.0 2.1 2.2 2.3 2.4 Medical Knowledge Self Assessment Program (MKSAP) 17, 18, 19. American College of Physicians, Philadelphia 2015, 2018, 2021.
- ↑ WHO classification of Tumors of the Central Nervous System. 4th edition. IARC 2007.