acute basophilic leukemia
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Introduction
Acute myeloid leukemia with primary differentiation toward basophils
Epidemiology
- rare; < 1% of leukemias
Microscopic pathology
- medium sized blasts, high nuclear/cytoplasmic ratio
- moderately basophilic cytoplasm,
- variable numbers of coarse basophilic granules
Immunophenotype
- myeloid markers: CD13, CD33
- early hematopoietic markers: CD34, class-II HLA-DR
- CD9
- some TdT
- negative for lymphoid markers
Genetics
no consistent chromosomal abnormality identified
Clinical manifestations
- features related to bone marrow failure
- circulating blasts +/-
- organomegaly +/-
- cutaneous involvement +/-
- lytic lesions +/-
- symptoms of hyperhistaminemia +/-
More general terms
Additional terms
References
- ↑ WHO Classification Tumours of Haematopoietic and Lymphoid Tissues. IARC Press 2001
- ↑ Khattar P, YaBE M Leukemia acute AML not otherwise categorized Acute basophilic leukemia Pathology Outlines http://www.pathologyoutlines.com/topic/leukemiabasophil.html