pituitary adenoma/non-secreting
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Introduction
Most non-secreting pituitary adenomas actually secrete gonadotropins, their subunits or both.
Genetics
- comparing different pituitary adenoma types & normal pituitary:
- genes uniquely overexpressed 2x or >:
- guanine nucleotide binding protein, beta polypeptide
- ATPase, Ca+2 transporting, plasma membrane 1
- glutamate cysteine ligase
- ubiquitin specific protease 9, Y chromosome
- KIAA0591 protein
- KIAA0911 protein
- CBP/p300-interacting transactivator
- histone deacetylase 1
- cellular retinoic acid binding protein 2
- genes uniquely underexpressed 2x or >:
- genes uniquely overexpressed 2x or >:
- comparing with normal pituitary:
- genes overexpressed 2x or >: ?
- genes underexpressed 2x or >:
Radiology
- CT or MRI of sella turcica (preferably MRI); repeat in 6 months if no surgery[1]
Management
- - asymptomatic pituitary microadenomas do not require treatment[1]
- surgery is the only effective treatment
More general terms
Additional terms
References
- ↑ Jump up to: 1.0 1.1 1.2 Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 18, 19. American College of Physicians, Philadelphia 1998, 2006, 2018, 2022.
- ↑ Jump up to: 2.0 2.1 Evans CO et al Novel patterns of gene expression in pituitary adenomas identified by complementary deoxyribonucleic acid microarrays and quantitative reverse transcription-polymerase chain reaction. Journal Clinical Endocrinology & Metabolism 86:3097-3107, 2001 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11443173