neuroserpin; serpin I1; peptidase inhibitor 12; PI-12 (SERPINI1, PI12)

Function

• serine protease inhibitor
• inhibits plasminogen activators & plasmin but not thrombin
• may be involved in formation or reorganization of synaptic connections as well as in synaptic plasticity in the adult nervous system
• may protect neurons from cell damage by tissue-type plasminogen activator

Structure

belongs to the serpin family

Compartment

secreted

Expression

predominantly expressed in the brain

Pathology

• defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies

More general terms

• glycoprotein
• protease inhibitor
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5274
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5274
• OMIM: https://mirror.omim.org/entry/602445
• OMIM: https://mirror.omim.org/entry/604218
• UniProt: http://www.uniprot.org/uniprot/Q99574.html