kinesin family member 1B (Kif1b, Klp, KIAA0591, KIAA1448)

Function

• motor for anterograde transport of mitochondria
• has a microtubule plus end-directed motility
• may function as a monomeric motor for anterograde transport of mitochondria

Structure

• belongs to the kinesin-like protein family, Unc-104 subfamily
• contains 1 FHA domain
• contains 1 kinesin-motor domain
• contains 1 PH domain

Compartment

• cytoplasmic vesicle (putative)
• cytoplasm, cytoskeleton (putative)
• predominantly found on the vesicle- & tubule-like structures within the cytoplasm

Alternative splicing

named isoforms=4

Expression

• isoform 3 is abundant in the skeletal muscle it is also expressed in fetal brain, lung & kidney, & adult heart, placenta, testis, ovary & small intestine
• isoform 2 is abundant in the brain & also expressed in fetal heart, lung, liver & kidney, & adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon & pancreas

Pathology

• defects in KIF1B are the cause of Charcot-Marie-Tooth disease type 2A1

More general terms

• kinesin family protein
• phosphoprotein

Additional terms

• mitochondria

Database

• OMIM: https://mirror.omim.org/entry/605995
• OMIM: https://mirror.omim.org/entry/118210
• UniProt: http://www.uniprot.org/uniprot/O60333.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23095