ATP-grasp domain

Introduction

Contains an unusual nucleotide-binding fold

Found in:

• D-alanine-D-alanine ligase
• glutathione synthetase
• biotin carboxylase
• carbamoyl phosphate synthetase
• ribosomal protein S6 modification enzyme RimK
• urea amidolyase
• tubulin-tyrosine ligase
• enzymes of purine biosynthesis

May confer ATP-dependent carboxylate-amine ligase activity

Likely to include acylphosphate intermediates.

More general terms

• ATP-binding site or Rossmann motif
• domain