tubulin-tyrosine ligase (TTL)

Function

• catalyzes the posttranslational addition of Tyr to the C-terminal end of detyrosinated alpha-tubulin

ATP + detyrosinated alpha-tubulin + L-tyrosine
           <-->  alpha-tubulin + ADP + phosphate

Cofactor: Mg+2, K+

Structure

• monomer
• contains 1 TTL domain

More general terms

• tyrosine kinase (protein tyrosine kinase, PTK)

Database

• OMIM: https://mirror.omim.org/entry/608291
• UniProt: http://www.uniprot.org/uniprot/Q8NG68.html