mdm2 proto-oncogene
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Introduction
Gene amplified in 17 of 47 sarcomas. In addition to p53, MDM2 gene is also regulated by the Ras/Raf/MEK/MAP kinase pathway through activation of Ets & AP-1 sites in the P2 promoter upstream from & independent of the p53 response element[3]
More general terms
References
- ↑ Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B. Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature. 1992 Jul 2;358(6381):80-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1614537
- ↑ Lane DP. Cancer. p53, guardian of the genome. Nature. 1992 Jul 2;358(6381):15-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1614522
- ↑ 3.0 3.1 Ries S, Biederer C, Woods D, Shifman O, Shirasawa S, Sasazuki T, McMahon M, Oren M, McCormick F. Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF. Cell. 2000 Oct 13;103(2):321-30. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11057904