BDNF gene
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Pathology
- common point mutation, methionine for valine, is present in ~30% of humans.
- BDNF Val66Met mutation associated with
- lower scores on tests of episodic memory, but not other cognitive tests[1]
- slower movement of BDNF towards synapse & inadequate secretion
- faster cognitive decline in Alzheimer's disease[2]
- lower BDNF production
- decreased hippocampal volume
- amyloid may exacerbate[2]
More general terms
References
- ↑ 1.0 1.1 Journal Watch 23(6):48, 2003
Egan MF, Kojima M, Callicott JH et al The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003 Jan 24;112(2):257-69. PMID: https://www.ncbi.nlm.nih.gov/pubmed/12553913 Free Article - ↑ 2.0 2.1 2.2 Kneisel K Gene Linked to Steeper Cognitive Declines in AD - Decline exacerbated by greater b-amyloid burden. MedPage Today. May 4, 2017 https://www.medpagetoday.com/Neurology/AlzheimersDisease/65016
Boots EA, Schultz SA, Clark LR et al BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention. Neurology 2017;88:1-9 PMID: https://www.ncbi.nlm.nih.gov/pubmed/28468845