inhibitor of Bruton tyrosine kinase (IBTK, BTKI, KIAA1417)

Function

• inhibits BTK tyrosine kinase activity leading to interference with BTK-mediated Ca+2 mobilization & NF-kappa-B-driven transcription
• interacts with the PH domain of BTK
• role in B-cell development

Structure

• contains 3 ANK repeats
• contains 2 BTB domains (POZ domains)
• contains 3 RCC1 repeats

Compartment

• cytoplasm,peripheral membrane
• ranslocates to plasma membrane upon IgM stimulation.

Alternative splicing

named isoforms=4

Expression

• highly expressed in hemopoietic tissues: fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow
• weakly or not expressed in other tissues

More general terms

• enzyme inhibitor
• phosphoprotein

Additional terms

• Bruton tyrosine kinase; agammaglobulinemia tyrosine kinase; ATK; B-cell progenitor tyrosine kinase (BPK, BTK, AGMX1)

Database

• OMIM: https://mirror.omim.org/entry/606457
• UniProt: http://www.uniprot.org/uniprot/Q9P2D0.html