neurturin (NRTN)

Function

• supports survival of sympathetic neurons in culture
• may regulate development & maintenance of the CNS
• might control the size of non-neuronal cell population such as haemopoietic cells

Structure

• homodimer; disulfide-linked
• belongs to the TGF-beta family, GDNF subfamily

Compartment

secreted

Pathology

• genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, & possibly mutations in other loci

More general terms

• growth factor
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4902
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4902
• OMIM: https://mirror.omim.org/entry/602018
• UniProt: http://www.uniprot.org/uniprot/Q99748.html