teratocarcinoma-derived growth factor 3; cripto-3 growth factor; epidermal growth factor-like cripto protein CR3; teratocarcinoma-derived growth factor 1 pseudogene 3 (TDGF1P3, CRIPTO3, TDGF2, TDGF3)

Function

• may play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm
• activates the nodal-dependent signaling pathway

Structure

contains 1 EGF-like domain

Compartment

cell membrane

Expression

• expressed weakly in lung, colon & breast
• expressed strongly in primary cancer tissues; lung cancer & colon cancer

Notes

• could be the product of a pseudogene
• the TDGF3 locus has characteristics of a retrotransposon, including lack of introns & a poly(A) sequence

More general terms

• growth factor
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/187395
• UniProt: http://www.uniprot.org/uniprot/P51864.html