lipocortin-1; annexin-A1; ANXA1; calpactin-2; chromobindin-9; phospholipase-A2 inhibitory protein (ANXA1)
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Function
- Ca+2/phospholipid-binding protein
- promotes membrane fusion & is involved in exocytosis
- protein regulates phospholipase A2 activity
- seems to bind from 2-4 Ca+2 with high affinity
- phosphorylated by protein kinase C, EGFR & TRPM7
- phosphorylation results in loss of inhibitory activity
Structure
- homodimer in placenta (20%); linked by transglutamylation
- a pair of annexin repeats may form one binding site for Ca+2 & phospholipid
- belongs to the annexin family
- contains 4 annexin repeats
Compartment
- nucleus (putative), cytoplasm
- cell projection, cilium (putative)
- basolateral cell membrane (putative)
- found in the cilium, nucleus & basolateral cell membrane of ciliated cells in the tracheal endothelium (putative)
- found in the cytoplasm of type 2 pneumocytes & alveolar macrophages (putative)