transient receptor potential cation channel subfamily M member 7; channel-kinase 1; long transient receptor potential channel 7; LTrpC-7; LTrpC7 (TRPM7, CHAK1, LTRPC7)

Function

• ion channel & serine/threonine protein kinase*
• divalent cation channel permeable to Ca+2 & Mg+2
• role in magnesium ion homeostasis
• regulation of anoxic neuronal cell death
• may be involved in a process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell
• phosphorylates annexin A1 (ANXA1)
• autophosphorylated (putative)
• forms heterodimers with TRPM6
• interacts with PLCB1 (putative)

Cofactor:

• binds 1 Zn+2 per subunit (putative)

* kinase activity essential for the channel function

Structure

• in the C-terminal section; belongs to the protein kinase superfamily, alpha-type protein kinase family, ALPK subfamily
• in the N-terminal section; belongs to the transient receptor (TC 1.A.4) family, LTrpC subfamily, TRPM7 sub-subfamily
• contains 1 alpha-type protein kinase domain

Compartment

membrane (probable)

Pathology

• defects in TRPM7 are a cause of susceptibility to amyotrophic lateral sclerosis-parkinsonism/dementia complex type 1

More general terms

• transmembrane 6 protein
• ion channel
• serine/threonine kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54822
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54822
• OMIM: https://mirror.omim.org/entry/105500
• OMIM: https://mirror.omim.org/entry/605692
• UniProt: http://www.uniprot.org/uniprot/Q96QT4.html