histidine triad nucleotide-binding protein 1; adenosine 5'-monophosphoramidase; protein kinase C inhibitor 1; protein kinase C-interacting protein 1; PKCI-1 (HINT1, HINT, PKCI1, PRKCNH1)

Function

• hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester & AMP-NH2 (putative)
• interacts with CDK7

Structure

• homodimer
• histidine triad, also called HIT motif, forms part of binding loop for alpha-phosphate of purine mononucleotide
• belongs to the HINT family
• contains 1 HIT domain

Compartment

• cytoplasm, nucleus
• interaction with CDK7 leads to a more nuclear localization

Expression

• widely expressed

Notes

• originally thought to be a protein kinase C inhibitor & to bind Zn+2 in solution
• neither appears to be so

More general terms

• phosphatase inhibitor
• HIT (histidine triad) family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3094
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3094
• OMIM: https://mirror.omim.org/entry/601314
• UniProt: http://www.uniprot.org/uniprot/P49773.html