calcitonin gene-related peptide 1; alpha-type CGRP; calcitonin gene-related peptide I; CGRP-I (CALCA, CALC1)

Function

• induces vasodilation
• it dilates a variety of vessels including the coronary arteries, cerebral arteries & systemic vasculature
• abundance in the CNS suggests a neurotransmitter or neuromodulator role
• elevates platelet cAMP

Structure

• belongs to the calcitonin familyStructure:
• alpha-CGRP differs from beta-CGRP (CALCB) by single amino acid

Compartment

secreted

Alternative splicing

• named isoforms=3
• at least one iform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Genetics

• encoded by a gene separate from CALCB

More general terms

• calcitonin gene-related peptide (CGRP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=796
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:796
• OMIM: https://mirror.omim.org/entry/114130
• UniProt: http://www.uniprot.org/uniprot/P06881.html