melanoma-associated antigen 11; MAGE-11 antigen; cancer/testis antigen 1.11; CT1.11 (MAGEA11, MAGE11)

Function

• acts as androgen receptor co-regulator that increases androgen receptor activity by modulating the receptors interdomain interaction
• may play a role in embryonal development, tumor transformation or aspects of tumor progression

Structure

contains 1 MAGE domain

Compartment

nucleus, cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in tumors of several types, including melanoma, head & neck squamous cell carcinoma, lung carcinoma & breast carcinoma
• expressed in testis, ovary, prostate, cancerous prostate, breast & adrenal tissue

More general terms

• melanoma associated antigen (MAGE)
• nuclear protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P43364.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4110
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4110
• OMIM: https://mirror.omim.org/entry/300344