melanoma-associated antigen 2; MAGE-2 antigen; cancer/testis antigen 1.2; CT1.2 (MAGEA2, MAGE2, MAGEA2A, MAGEA2B, MAGE2, MAGEA2)

Function

• unknown
• may play a role in embryonal development, tumor transformation or aspects of tumor progression
• antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

Structure

contains 1 MAGE domain

Expression

• expressed in many tumors of several types, including: melanoma, head & neck squamous cell carcinoma, lung carcinoma & breast carcinoma
• not expressed in normal tissues except testes

More general terms

• melanoma associated antigen (MAGE)

Database

• UniProt: http://www.uniprot.org/uniprot/P43356.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=266740
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4101
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:266740
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4101
• OMIM: https://mirror.omim.org/entry/300173
• OMIM: https://mirror.omim.org/entry/300549