melanoma-associated antigen 1; MAGE-1 antigen; antigen MZ2-E; cancer/testis antigen 1.1; CT1.1 (MAGEA1, MAGE1, MAGE1A)

Function

• unknown
• may play a role in embryonal development, tumor transformation or aspects of tumor progression
• antigen recognized on a melanoma by autologous cytolytic T-lymphocytes

Structure

contains 1 MAGE domain

Compartment

cytoplasm

Expression

• expressed in many tumors of several types, including : melanoma, head & neck squamous cell carcinoma, lung carcinoma & breast carcinoma
• not expressed in normal tissues except for testes
• not expressed in renal carcinomas, leukemias or lymphomas

More general terms

• melanoma associated antigen (MAGE)

Database

• UniProt: http://www.uniprot.org/uniprot/P43355.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4100
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4100
• OMIM: https://mirror.omim.org/entry/300016