GDNF family receptor alpha-3; GFR-alpha-3; glial derived neurotrophic factor [GDNF] receptor alpha-3(GFRA3)

Function

• receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin)
• mediates the artemin-induced autophosphorylation & activation of the RET receptor tyrosine kinase

Structure

• N-glycosylated
• glycosylphosphatidylinositol-linked cell surface receptor
• belongs to the GDNFR family

Compartment

cell membrane; lipid-anchor, GPI-anchor

Alternative splicing

named isoforms=2

Expression

• widely expressed in adult & fetus which exhibit a similar pattern
• essentially not expressed in the central nervous system, but highly expressed in several sensory & sympathetic ganglia of the peripheral nervous system
• moderate expression in digestive & urogenital systems with high expression in stomach & appendix
• low expression in several glandular tissues
• very low or no expression in the hematopoietic system

More general terms

• glial derived neurotrophic factor [GDNF] receptor alpha

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2676
• OMIM: https://mirror.omim.org/entry/605710
• UniProt: http://www.uniprot.org/uniprot/O60609.html