GDNF family receptor alpha-2; GFR-alpha-2; glial derived neurotrophic factor [GDNF] receptor alpha-2; neurturin receptor alpha; NRTNR-alpha; NTNR-alpha; TGF-beta-related neurotrophic factor receptor 2; GDNF receptor beta; GDNFR-beta; RET ligand 2 (GFRA2 GDNFRB RETL2 TRNR2)

Function

• receptor for neurturin
• mediates the NRTN-induced autophosphorylation & activation of the RET receptor
• also able to mediate GDNF signaling through the RET tyrosine kinase receptor

Structure

• glycosylphosphatidylinositol-linked cell surface receptor
• belongs to the GDNFR family

Compartment

cell membrane; lipid-anchor, GPI-anchor (By similarity)

Alternative splicing

named isoforms=2

Expression

isoform 1 is found in both brain & placenta

More general terms

• glial derived neurotrophic factor [GDNF] receptor alpha

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2675
• OMIM: https://mirror.omim.org/entry/601956
• UniProt: http://www.uniprot.org/uniprot/O00451.html