pre T-cell antigen receptor alpha (pTa, pT-alpha, pT-alpha-TCR) (PTCRA)

Function

• component of pre-T-cell receptor complex
• heterodimer with TCRB; disulfide linked
• heterodimer assembles with CD3 proteins into a signaling-competent pre-T-cell receptor complex

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in immature but not mature T-cells
• also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood & adult bone marrow
• expressed in fetal life in CD34+ progenitors
• present in the liver at 18 weeks of gestation but is absent in CD34+ precursors from fetal bone marrow at any developmental stage up to 22 weeks

More general terms

• receptor
• glycoprotein
• membrane protein

Component of

• pre-T-cell receptor complex

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1715
• OMIM: https://mirror.omim.org/entry/606817
• UniProt: http://www.uniprot.org/uniprot/Q6ISU1.html