receptor-type tyrosine-protein phosphatase R; R-PTP-R; Ch-1PTPase; NC-PTPCOM1; protein-tyrosine phosphatase PCPTP1 (PTPRR ECPTP PTPRQ)

Function

• sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 & MAPK14 in the cytoplasm in an inactive form
• the MAPKs bind to a dephosphorylated kinase-interacting motif, phosphorylation of which by protein kinase A releases the MAPKs for activation & translocation into the nucleus (putative)
• interacts with MAPKs (putative)

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family receptor class 7 subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

• isoform alpha:
  • cell membrane; single-pass type 1 membrane protein
• isoform delta:
  • cytoplasm, perinuclear region
  • locates to the perinuclear areas within the cytoplasm
• isoform gamma
  • cytoplasm, perinuclear region
  • locates to the perinuclear areas within the cytoplasm

Alternative splicing

named isoforms=3; alpha, gamma, delta

Expression

• expressed in brain, placenta, small intestine, stomach, uterus
• weakly expressed in the prostate
• isoform alpha has been observed only in the brain
• isoform gamma is expressed in brain, placenta & uterus
• isoform delta is expressed in brain, kidney, placenta, prostate, small intestine & uterus

More general terms

• tyrosine phosphatase, receptor type
• receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5801
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5801
• OMIM: https://mirror.omim.org/entry/602853
• UniProt: http://www.uniprot.org/uniprot/Q15256.html