receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; phogrin (PTPRN2, KIAA0387)

Function

• role in development of nervous system & pancreatic endocrine cells
• appears to undergo multiple proteolytic cleavage at consecutive basic residues

Kinetic parameters:

• pH dependence:
• Optimum pH is 4.5

protein tyrosine phosphate + H2O = protein tyrosine + phosphate

Structure

• the cytoplasmic domain appears to contain the autoantigenic epitopes
• belongs to the protein-tyrosine phosphatase family receptor class 8 subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

• membrane; single-pass type 1 membrane protein (probable)

Alternative splicing

named isoforms=3

Expression

• highest levels in brain & pancreas
• lower levels in trachea, prostate, stomach & spinal cord

Pathology

• autoantigen in insulin-dependent diabetes mellitus (IDDM)

More general terms

• tyrosine phosphatase, receptor type
• receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5799
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5799
• OMIM: https://mirror.omim.org/entry/601698
• UniProt: http://www.uniprot.org/uniprot/Q92932.html