neuromodulin; axonal membrane protein GAP-43; growth-associated protein 43; PP46; neural phosphoprotein B-50 (GAP43)

Function

• associated with nerve growth
• major component of the motile growth cones that form the tips of elongating axons (1% of total growth cone membrane protein)
• phosphorylation by a protein kinase C is associated with certain forms of synaptic plasticity
• binds calmodulin with a greater affinity in the absence of Ca+2 than in its presence (putative)
• inhibits PIP kinase
• regulates binding of GTP to Go

Structure

• belongs to the neuromodulin family
• contains 1 IQ domain

Compartment

• cell membrane
• peripheral membrane protein cytoplasmic side
• cell projection, growth cone membrane
• cell junction, synapse
• cytoplasmic surface of growth cone & synaptic plasma membranes

More general terms

• plasma membrane protein
• calmodulin binding protein
• PEST protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2596
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2596
• OMIM: https://mirror.omim.org/entry/162060
• UniProt: http://www.uniprot.org/uniprot/P17677.html