transcription factor YY2 (Yin & yang 2, YY-2, zinc finger protein 631, YY2, ZNF631)

Function

• multifunctional transcription factor
• may exhibit positive & negative control on a large number of genes
• may antagonize YY1 & function in development & differentiation

Structure

• belongs to the YY transcription factor family
• contains 4 C2H2-type Zn+2 fingers

Compartment

nucleus (probable)

Expression

• expressed in kidney, liver, spleen & testis
• not expressed in colon

Notes

• gene encoding this protein appears to have arisen by retrotransposition of the YY1 gene in placental mammals
• encoded by a single exon found in an intron of the gene MBTPS2

More general terms

• C2H2 type zinc finger protein
• transcription factor (TF)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4042
• UniProt: http://www.uniprot.org/uniprot/O15391.html