transcription factor RFX4 (regulatory factor X 4, testis development protein NYD-SP10, RFX4)

Function

• may activate transcription by interacting directly to the X-box (putative)

Structure

• homodimer
• heterodimer with RFX2 & RFX3
• binds DNA
• belongs to the RFX family

Compartment

nucleus (putative)

Alternative splicing

named isoforms=4

Expression

• isoform 4 is testis-specific
• isoform 1 is expressed in brain & gliomas
• isoform 2 & isoform 3 are testis-specific (at protein level)
• isoform 1 is expressed in brain (at protein level)
• isoform 3 is higher expressed in adult testes & ejaculated spermatozoa than in fetal testes

More general terms

• DNA-binding protein
• transcription factor (TF)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5992
• OMIM: https://mirror.omim.org/entry/603958
• UniProt: http://www.uniprot.org/uniprot/Q33E94.html