grainyhead-like protein 1 homolog (transcription factor CP2-like 2, transcription factor LBP-32, NH32, mammalian grainyhead, GRHL1, LBP32, MGR, TFCP2L2)

Function

• transcription factor
• isoform 1 may function as an activator & isoform 2 as a repressor in tissues where both forms are expressed
• role in development (putative)
• role in epidermal differentiation (putative)
• binds & transactivates the EN1 promoter
• homodimer, also forms heterodimers with GRHL2 or GRHL3

Structure

belongs to the grh/CP2 family, Grainyhead subfamily

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• isoform 1 is highly expressed in brain, pancreas, tonsil, placenta & kidney
• isoform 2 is highly expressed in brain & liver
• highly expressed in placental JEG-3 cells & at very low levels in non-steroidogenic cells
• no expression detected in adrenal NCI-H295A cells
• expressed in fetal liver & brain

More general terms

• transcription factor (TF)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NZI5.html