grainyhead-like protein 2 homolog (brother of mammalian grainyhead, transcription factor CP2-like 3, GRHL2, BOM, TFCP2L3)

Function

• transcription factor

Structure

• homodimer, also forms heterodimers with GRHL1 or GRHL3

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• expressed in placenta, prostate, brain, kidney > epithelial tissues of thymus, kidney, lung, salivary gland, mammary gland, digestive tract
• expressed in cochlea

Pathology

• defects in GRHL2 are the cause of autosomal dominant nonsyndromic sensorineural deafness 28

More general terms

• transcription factor (TF)

Database

• OMIM: https://mirror.omim.org/entry/608576
• OMIM: https://mirror.omim.org/entry/608641
• UniProt: http://www.uniprot.org/uniprot/Q6ISB3.html