cAMP responsive element-binding protein 3-like protein 3 (transcription factor CREB-H, CREB3L3, CREBH, HYST1481)
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Function
- transcription factor
- may act during endoplasmic reticulum stress via activating unfolded protein response target genes
- activated in response to cAMP stimulation
- in vitro, binds to the cAMP response element (CRE) & box-B element
- activates transcription through box-B element
- activates transcription through CRE
- functions synergistically with ATF6
- in acute inflammatory response, may activate expression of acute phase response (APR) genes
- role in growth suppression (putative)
- binds DNA as a dimer
- homodimerizes
- forms a heterodimer with ATF6
- interacts with ATF6
- controlled by regulated intramembrane proteolysis
- following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis
Structure
- belongs to the bZIP family, ATF subfamily
- contains 1 bZIP domain
Compartment
- endoplasmic reticulum membrane
- single-pass type II membrane protein
- processed form: nucleus
- under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus
Alternative splicing
named isoforms=3
Expression
- exclusively expressed in liver
- underexpressed in hepatocellular carcinoma tissues