nuclear respiratory factor 1; NRF-1; alpha palindromic-binding protein; alpha-pal (NRF1)

Function

• transcription factor
• activates expression of the EIF2S1 (EIF2-alpha) gene
• links transcriptional modulation of key metabolic genes to cellular growth & development
• implicated in control of nuclear genes required for respiration, heme biosynthesis, & mitochondrial DNA transcription & replication
• phosphorylation enhances DNA binding
• homodimer
• binds DNA as a dimer
• interacts with PPRC1

Structure

belongs to the NRF1/Ewg family

Compartment

nucleus

Alternative splicing

named isoforms=2; long, short

Expression

• ubiquitously expressed
• strongest expression in skeletal muscle

More general terms

• transcription factor (TF)
• phosphoprotein
• DNA-binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4899
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4899
• OMIM: https://mirror.omim.org/entry/600879
• UniProt: http://www.uniprot.org/uniprot/Q16656.html