peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator, PRC, PPRC1, KIAA0595)

Function

• coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis & cell growth
• role in transcription coactivation of CREB & NRF1 target genes
• interacts with CREB1 & NRF1

Structure

contains 1 RRM (RNA recognition motif) domain

Compartment

• nucleus
• colocalizes with NRF1

Alternative splicing

named isoforms=2

Expression

• expressed in heart & skeletal muscle > lung, placenta, intestine, liver, kidney, spleen, thymus, colon & brain
• up-regulated by serum (at protein level)

Pathology

• expressed in several oncocytic thyroid tumors

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5VV67.html