nucleoside diphosphate kinase-B (NDP kinase B, c-myc purine-binding transcription factor PUF, nm23-H2, NME2)

Function

• major role in the synthesis of nucleoside triphosphates other than ATP
• negatively regulates Rho activity by interacting with AKAP13/LBC
• acts as a transcriptional activator of the c-Myc gene
• binds DNA nonspecifically
• N-terminus is blocked

ATP + nucleoside diphosphate <--> ADP + nucleoside triphosphate

Cofactor: Mg+2 (putative)

Structure

• hexamer of two different chains: A & B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). interacts with AKAP13
• belongs to the NDK family

Compartment

cytoplasm. nucleus

Pathology

• found in diminished amount in tumor cells of high metastatic potential

More general terms

• nucleoside diphosphate kinase (NDK) or NDP kinase
• transcription factor (TF)
• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/P22392.html
• OMIM: https://mirror.omim.org/entry/156491