lupus Ku autoimmune antigen, ATP-dependent DNA helicase-2, CTC box binding factor (CTCBF) or thyroid-lupus autoantigen (TLAA)
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Function
- Ku is a regulatory component of the DNA-associated kinase that phosphorylates RNA polymerase 2 & transcription factor SP1
- targets DNA-dependent protein kinase to DNA termini or other discontinuities in DNA structure
- Ku also activates transcription from U1 small nuclear RNA & the human transferrin receptor gene
- by virtue of its homology with rat Enhancer 1 binding factor, Ku may also be essential for RNA polymerase 1-directed transcription Structurre:
- heterodimer of XRCC5/XRCC6
Pathology
- autoantibodies to Ku protein are found in patients with
- systemic lupus erythematosus (SLE)
- scleroderma/polymyositis overlap syndrome
- other rheumatic diseases
More general terms
- helicase (DNA unwinding protein, DNA untwisting protein)
- DNA-binding protein
- transcription factor (TF)
- molecular complex
Component of
References
- ↑ Hoff CM, Ghosh AK, Prabhakar BS, Jacob ST. Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation. Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):762-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8290597