N-acetylglucosamine-1-phosphotransferase subunits gamma (GlcNAc-1-phosphotransferase subunit gamma, UDP-N-acetylglucosamine-1-phosphotransferase, subunit gamma, GNPTG, GNPTAG, CAB56184, LP2537)

Function

• recognizes substrate of GlcNAc-1-phosphotransferase & lysosomal proteins with mannose-6-phosphate residues

Structure

contains 1 PRKCSH domain

Compartment

secreted (putative), Golgi

Expression

widely expressed

Pathology

• defects in GNPTG are the cause of mucolipidosis 3C

More general terms

• enzyme regulatory subunit

Additional terms

• mucolipidosis

Component of

• N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8457
• OMIM: https://mirror.omim.org/entry/252605
• OMIM: https://mirror.omim.org/entry/607838
• UniProt: http://www.uniprot.org/uniprot/Q9UJJ9.html