N-acetylglucosamine-1-phosphotransferase (GlcNAc-1-phosphotransferase)

Function

• catalyzes the formation of mannose 6-phosphate markers on high mannose type oligosaccharides in the Golgi

Structure

• hexamer of two alpha, two beta & two gamma subunits, disulfide-linked
• the alpha &/or beta subunit(s) are catalytic, the gamma subunit functions in recognition of lysosomal enzymes

Compartment

Golgi membrane

Expression

• expressed in the heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas

More general terms

• phosphotransferase
• multisubunit protein

Additional terms

• cation-dependent mannose-6-phosphate receptor; CD man-6-P receptor; CD-MPR; 46 kD mannose 6-phosphate receptor; MPR 46 (M6PR, MPR46, MPRD)
• mannose-6-phosphate
• mucolipidosis
• stealth protein