STAT1/STAT3 complex
Jump to navigation
Jump to search
Introduction
Complex of IFN gamma-activated factor (STAT1) & STAT3.
Function
- may play role in regulation of cell cycle, since
- STAT1 is a tumor suppressor
- STAT3 promotes melanoma progression[2]
More general terms
References
- ↑ Zhang X, Blenis J, Li HC, Schindler C, Chen-Kiang S. Requirement of serine phosphorylation for formation of STAT- promoter complexes. Science. 1995 Mar 31;267(5206):1990-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/7701321
- ↑ 2.0 2.1 Wang W et al. STAT3 as a biomarker of progression in atypical nevi of patients with melanoma: Dose:response effects of systemic IFN therapy. J Invest Dermatol 2008 Aug; 128:1997. PMID: https://www.ncbi.nlm.nih.gov/pubmed/18305569