mediator of RNA polymerase II transcription subunit 23; activator-recruited cofactor 130 kD component; ARC130; cofactor required for Sp1 transcriptional activation subunit 3; CRSP complex subunit 3; mediator complex subunit 23; protein sur-2 homolog; hSur-2; transcriptional coactivator CRSP130; vitamin D3 receptor-interacting protein complex 130 kD component; DRIP130 (MED23, ARC130, CRSP3, DRIP130, KIAA1216, SUR2)

Function

• required for transcriptional activation subsequent to assembly of the preinitiation complex (putative)
• component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes
• required for transcriptional activation by adenovirus E1A protein
• required for ELK1-dependent transcriptional activation in response to activated Ras signaling
• interacts with ELK1 (putative)
• interacts with CEBPB, CTNNB1, & GLI3
• interacts with the adenovirus E1A protein

Structure

• belongs to the mediator complex subunit 23 family

Compartment

nucleus (probable)

Alternative splicing

named isoforms=5

More general terms

• transcription factor (TF)
• phosphoprotein

Component of

• activator-recruited cofactor (ARC)/DRIP
• mediator complex (mediator of RNA polymerase 2 transcription)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9439
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9439
• OMIM: https://mirror.omim.org/entry/605042
• UniProt: http://www.uniprot.org/uniprot/Q9ULK4.html