amiloride-sensitive cation channel 5; human intestine Na+ channell hINaC (ACCN5, ASIC5, HINAC)

Function

• cation channel that gives rise to very low constitutive currents in the absence of activation
• the activated channel exhibits selectivity for Na+
• inhibited by amiloride

Structure

• homotetramer or heterotetramer (putative)
• belongs to the amiloride-sensitive Na+ channel family

Compartment

cell membrane

Expression

• detected in small intestine, duodenum & jejunum
• detected at very low levels in testis & rectum

More general terms

• glycoprotein
• amiloride-sensitive cation channel

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5180
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51802
• UniProt: http://www.uniprot.org/uniprot/Q9NY37.html