C-type lectin domain family 12 member B (macrophage antigen H, CLEC12B)

Function

• cell surface receptor
• protects target cells against NK cell-mediated lysis
• modulates signaling cascades
• mediates tyrosine phosphorylation of target MAP kinases
• interacts with PTPN6 & PTPN11

Structure

• homodimer
• contains 1 ITIM motif
• the phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases
• contains 1 C-type lectin domain

Compartment

cell membrane

Alternative splicing

named isoforms=2

Expression

• detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen & testis

More general terms

• phosphoprotein
• glycoprotein
• membrane protein
• C-type lectin superfamily

Database

• UniProt: http://www.uniprot.org/uniprot/Q2HXU8.html