C-type lectin domain family 1 member B (C-type lectin-like receptor 2, CLEC-2, CLEC1B, CLEC2, UNQ721/PRO1384)

Function

• phosphorylated on Tyr in response to rhodocytin binding

Structure

• glycosylated
• contains 1 C-type lectin domain

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed preferentially in liver
• expressed in immune cells of myeloid origin & on surface of platelets

Pathology

• receptor for platelet-aggregating snake venom protein rhodocytin
• rhodocytin binding leads to Tyr phosphorylation & this promotes binding of spleen tyrosine kinase (Syk) & initiation of downstream Tyr phosphorylation events & activation of PLC-gamma-2
• acts as an attachment factor for HIV-1, thus facilitates its capture by platelets

More general terms

• C-type lectin superfamily
• membrane protein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606783
• UniProt: http://www.uniprot.org/uniprot/Q9P126.html