protein phosphatase 1 regulatory subunit 14D; gastrointestinal & brain-specific PP1-inhibitory protein 1; GBPI-1 (PPP1R14D GBPI)

Function

• inhibitor of PPP1CA
• has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates & smooth muscle contraction
• phosphorylated on several residues

Structure

belongs to the PP1 inhibitor family

Compartment

cytoplasm (probable)

Expression

• detected in colon, intestine, kidney & cerebral cortex

More general terms

• protein phosphatase-1 regulatory subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54866
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54866
• OMIM: https://mirror.omim.org/entry/613256
• UniProt: http://www.uniprot.org/uniprot/Q9NXH3.html