protein phosphatase 1 regulatory subunit 14C; kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; serologically defined breast cancer antigen NY-BR-81 (PPP1R14C, KEPI)

Function

• inhibitor of PPP1CA
  • > 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating phosphorylation status of PPP1CA substrates & smooth muscle contraction (putative)

Structure

belongs to the PP1 inhibitor family

Compartment

• cytoplasm (putative)
• peripheral membrane (putative)

Expression

detected in breast cancer

More general terms

• protein phosphatase-1 regulatory subunit
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=81706
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:81706
• OMIM: https://mirror.omim.org/entry/613242
• UniProt: http://www.uniprot.org/uniprot/Q8TAE6.html