bone morphogenetic protein 3; BMP-3; bone morphogenetic protein 3A; BMP-3A; osteogenin (BMP3, BMP3A)

Function

• negatively regulates bone density
• antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation & ossification

Structure

• homodimer; disulfide-linked (putative)
• belongs to the TGF-beta family

Compartment

secreted

Expression

• expressed in adult & fetal cartilage
• highly expressed in fracture tissue, particularly in osteoblasts, osteoclasts & chondroblasts

More general terms

• bone morphogenetic protein (BMP)
• TGF-beta family protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=651
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:651
• OMIM: https://mirror.omim.org/entry/112263
• UniProt: http://www.uniprot.org/uniprot/P12645.html