fibroblast growth factor 20; FGF-20 (FGF20)

Function

• neurotrophic factor that regulates central nervous system development & function
• interacts with FGFR2 & FGFR4
• affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Structure

• homodimer
• belongs to the heparin-binding growth factors family

Compartment

secreted

Expression

• predominantly expressed in the cerebellum

More general terms

• fibroblast growth factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26281
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26281
• OMIM: https://mirror.omim.org/entry/605558
• UniProt: http://www.uniprot.org/uniprot/Q9NP95.html