fibroblast growth factor 17; FGF-17 (FGF17)

Function

• role in regulation of embryonic development & as signaling molecule in the induction & patterning of the embryonic brain
• required for normal brain development
• interacts with FGFR3 & FGFR4

Structure

• belongs to the heparin-binding growth factors family

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• preferentially expressed in the embryonic brain
• detected in embryos at E14.5
• not detected at E10.5 & E19.5
• preferentially expressed in the neuroepithelia of the isthmus & septum of the embryonic brain at E14.5

More general terms

• fibroblast growth factor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8822
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8822
• OMIM: https://mirror.omim.org/entry/603725
• UniProt: http://www.uniprot.org/uniprot/O60258.html