fibroblast growth factor 6; FGF-6; heparin secretory-transforming protein 2; HST-2; HSTF-2; heparin-binding growth factor 6; HBGF-6 (FGF6, HST2, HSTF2)

Function

• role in the regulation of cell proliferation, cell differentiation, angiogenesis & myogenesis, & is required for normal muscle regeneration
• interacts with FGFR1, FGFR2 & FGFR4
• affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Structure

• belongs to the heparin-binding growth factors family

Compartment

secreted, extracellular space

Expression

• leukemia cell lines with platelet/megakaryocytic differentiation potential

Genetics

• product of hst2 (human) oncogene.

More general terms

• fibroblast growth factor
• proto oncogene protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2251
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2251
• OMIM: https://mirror.omim.org/entry/134921
• UniProt: http://www.uniprot.org/uniprot/P10767.html