fibroblast growth factor 4; FGF-4; heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; heparin-binding growth factor 4; HBGF-4; transforming protein KS3 (FGF4, HST, HSTF1, KS3)

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Function

role in the regulation of embryonic development, cell proliferation, & cell differentiation
required for normal limb & cardiac valve development during embryogenesis
interacts with FGFR1, FGFR2, FGFR3 & FGFR4
affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors

Structure

belongs to the heparin-binding growth factors family

Compartment

secreted (putative)

Genetics

product of hst1 (human) or ks3 (mouse) proto-oncogene

More general terms

References

↑ UniProt http://www.uniprot.org/uniprot/P08620.html
↑ Cross M, Dexter TM. Growth factors in development, transformation, and tumorigenesis. Cell. 1991 Jan 25;64(2):271-80. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1988148
↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2249

Database

Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2249
Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2249
OMIM: https://mirror.omim.org/entry/164980
UniProt: http://www.uniprot.org/uniprot/P08620.html

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