C-X-C motif chemokine 2; growth-regulated protein beta; gro-beta; macrophage inflammatory protein 2-alpha; MIP2-alpha; contains: GRO-beta(5-73); GRO-beta-T; hematopoietic synergistic factor; HSF; SB-251353 (CXCL2, GRO2, GROB, MIP2A, SCYB2)

Function

• produced by activated monocytes & neutrophils
• expressed at sites of inflammation
• hematoregulatory chemokine
  • in vitro, suppresses hematopoietic progenitor cell proliferation
  • GRO-beta(5-73) shows a highly enhanced hematopoietic activity
• N-terminal processed form GRO-beta(5-73) is produced by proteolytic cleavage after secretion from bone marrow stromal cells

Structure

• belongs to the intercrine alpha (chemokine CxC) family

Compartment

secreted

Pharmacology

• GRO-beta(5-73) is available under the name Garnocestim as an immunomodulator

More general terms

• CXC chemokine; alpha chemokine
• gro proto-oncogene protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2920
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2920
• OMIM: https://mirror.omim.org/entry/139110
• UniProt: http://www.uniprot.org/uniprot/P19875.html